Endocrine Abstracts

IntroductionIrisin is a molecule secreted from skeletal muscle and contributes to maintenance of metabolic homeostasis leading to increased energy expenditure and reducing the risk of obesity and diabetes. Literature data suggest that patients with Cushing disease have lower irisin values than controls and remission of hypercortisolism increases these values. Moreover, other plasma inflammation markers implicated in the pathogenesis of atherosclerosis, i...

IntroductionRadioiodine whole-body scintigraphy plays an important role in the follow-up of patients with differentiated thyroid carcinoma (DTC), as it is highly accurate in detecting thyroid residues and recurrent disease. Unusual 131-iodine uptake outside the thyroid bed and areas of physiological uptake is strongly suggestive of distant metastasis. However, uncommon uptake may occur and lead to diagnostic errors.Case report<...

8-year-old girl is referred to a Pediatric Endocrinologist for the appearance of thelarche, first noted at 6.5 years. She had a relevant clinical history of a neonatal meningitis, requiring prolonged hospitalization and the need for ventriculoperitoneal shunt. On physical examination, she had breast development and dark, coarse pubic hair compatible with Tanner stage 3. She weighed 32.3 kg (percentile – Pc- 75–90), her height was 128 cm (Pc 50) and her annual growth ...

Vocal morbidity related to the external branch of the superior laryngeal nerve following thyroidectomyObjectives: Damage to the external branch of the superior laryngeal nerve (EBSLN) can cause a vocal morbidity following thyroidectomy. However its diagnosis is challenging. Here we aim to determine the vocal, endoscopic and acoustic characteristics of a damage of the EBSLN as well as factors associated to its occurrence.Materials a...

Objectives: Iodine intake affects the risk of thyroid disorders. This study aimed to calculate the overall incidence of thyroid dysfunctions and structural abnormalities in the Faroe Islands and to describe the relation to sex and age.Methods: We performed a nationwide, register-based study covering all 54,000 inhabitants of the Faroe Islands between 2006 and 2018. Cases were identified and classified by thyroid dysfunction using redeemed prescriptions o...

Objectives: Vocal alteration can occur following thyroidectomy with or without a damage of laryngeal nerves. Multiple factors can increase the risk of vocal alteration. We aim to determine the impact of surgery extent on vocal symptoms and endoscopic and acoustic findings.Materials and methods: In this prospective study, we evaluated the vocal alteration in patients undergoing a partial (PT) or total thyroidectomy (TT). We performed a vocal assessment pr...

Please Development and preliminary characterization of a simple human thyroid organoid in vitro model for thyroid metabolism investigation For decades, in vitro studies of the thyroid have relied on thyroid-derived tumor cell lines, which are limited by their undifferentiated phenotype, lack of response to TSH, and chromosomal abnormalities. A viable alternative are monolayer (2D) cultures of primary thyrocytes isolated from histologically normal thyroid glan...

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome (CS). Some familial forms have been associated to gene ARMC5 (Armadillo repeat-containing protein 5) inactivating mutations. This study aimed to evaluate the prevalence and the complications of ARMC5 mutations in our cohort of patients with bilateral adrenal incidentalomas (BAI).Methods: 72 patients, referred to our Center...

The highly toxic heavy metal Cadmium (Cd) is widely spread in the environment and could exert estrogen-like activity in tissues including breast. Previous studies demonstrated that Cd binds to estrogen receptor α positive (ERα+) breast cancer (BC) cells. In this new study, we evaluated effects of Cd on both ERα+ and ERα negative (ERα-) BC models with the aim to further characterize the mechanisms involved in Cd-related BC carcinogenesis. Specifically, ...

Objective: To compare the performances of the coronal contrast-enhanced T1-weighted (ceT1-w) and T2-weighted (T2-w) sequences, for the diagnosis of progression during the MRI follow-up of NFPAs.Materials and methods: 106 patients who had at least two MRIs for the follow-up of NFPA were retrospectively included. The largest diameter of the adenomas was measured on coronal ceT1-w and separately on T2-w sequences for all the MRIs of the follow-up, and by 2 ...